S. Farrag, O., Salman, D., Ali, F., S. Sayed, A., Mahmoud, M., A. Abd-El Raheem, A. (2020). Impact Of Continuous Treatment With Propylthiouracil On Renal And Hepatic Functions In Rabbits. Journal of Applied Veterinary Sciences, 5(2), 49-60. doi: 10.21608/javs.2020.85584
Omnia S. Farrag; Doaa Salman; Fatma Abo Zakaib Ali; Arafat S. Sayed; Motamed E. Mahmoud; Abd-El Raheem A. Abd-El Raheem. "Impact Of Continuous Treatment With Propylthiouracil On Renal And Hepatic Functions In Rabbits". Journal of Applied Veterinary Sciences, 5, 2, 2020, 49-60. doi: 10.21608/javs.2020.85584
S. Farrag, O., Salman, D., Ali, F., S. Sayed, A., Mahmoud, M., A. Abd-El Raheem, A. (2020). 'Impact Of Continuous Treatment With Propylthiouracil On Renal And Hepatic Functions In Rabbits', Journal of Applied Veterinary Sciences, 5(2), pp. 49-60. doi: 10.21608/javs.2020.85584
S. Farrag, O., Salman, D., Ali, F., S. Sayed, A., Mahmoud, M., A. Abd-El Raheem, A. Impact Of Continuous Treatment With Propylthiouracil On Renal And Hepatic Functions In Rabbits. Journal of Applied Veterinary Sciences, 2020; 5(2): 49-60. doi: 10.21608/javs.2020.85584
Impact Of Continuous Treatment With Propylthiouracil On Renal And Hepatic Functions In Rabbits
1Department of Animal Medicine, Faculty of Veterinary Medicine, Assiut University, Assiut; 71526, Egypt.
2Department of Animal Medicine, Faculty of Veterinary Medicine, Faculty of Veterinary Medicine, Sohag, University, Sohag, 82524, Egypt
3Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Sohag, University, Egypt.
4Professor of Animal Behaviour and Management, Faculty of Veterinary Medicine. Sohag University, Egypt
Receive Date: 03 February 2020,
Revise Date: 15 March 2020,
Accept Date: 30 March 2020
Abstract
This study was designed to investigate the effect of continuous treatment with the anti-thyroid drug, propylthiouracil (PTU), on renal and hepatic functions in rabbits as an experimental animal model. Animals were randomly divided into four different isolated groups (n = 10); Group I received normal saline. Group II, III, and IV were daily administrated with PTU in oral dosing of 50, 75, and 150 mg/kg, BWT, respectively, for three successive weeks. Serum T3 and T4 levels were measured in all groups. Increased serum creatinine and blood urea nitrogen levels (P<0.05) were also associated. Moreover, liver enzymes levels, aspartate aminotransferase, alanine aminotransferase, and total serum cholesterol levels showed a significant increase in a dose and time decedent manner. Thyroid glands of PTU-treated rabbits showed variable sized-follicles lined by multiple layers of follicular cells, which displayed signs of hyperactivity as the average follicular cell height. The diameter of its width was significantly increased compared with that in the control group. Besides, follicles were filled with a variable quantity of low-dense vacuolated colloids. Kidneys of such animals showed tubulointerstitial nephritis, glomerular atrophy, and multiple focal areas of mononuclear cell reaction. While the observed hepatic lesions were in the form of severe congestion in central vein and hepatic artery, hepatocellular necrosis, and granulocytic lymphoid cellular responses around portal areas associated with peri-portal fibrosis. Such lesions were dependent on doses of PTU. This study referred to that continuous treatment with an antithyroid drug PTU induced a hypothyroid state that was associated with impaired renal and hepatic functions in rabbits.
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