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Fayed, A., Salama, A., Ismaiel, I., Attia, T., A., E., Hassan, A. (2019). Protective Effects Of Solanium Nigrum Methanolic Extract Against Isoniazid/Rifampicin Induced Hepatotoxicity In Rats. Journal of Applied Veterinary Sciences, 4(2), 52-61. doi: 10.21608/javs.2019.63436
Abdel Hameed M. Fayed; Abeer A.A. Salama; Ismaiel E Ismaiel; Taha A. Attia; Elbatran Seham A.; Azza Hassan. "Protective Effects Of Solanium Nigrum Methanolic Extract Against Isoniazid/Rifampicin Induced Hepatotoxicity In Rats". Journal of Applied Veterinary Sciences, 4, 2, 2019, 52-61. doi: 10.21608/javs.2019.63436
Fayed, A., Salama, A., Ismaiel, I., Attia, T., A., E., Hassan, A. (2019). 'Protective Effects Of Solanium Nigrum Methanolic Extract Against Isoniazid/Rifampicin Induced Hepatotoxicity In Rats', Journal of Applied Veterinary Sciences, 4(2), pp. 52-61. doi: 10.21608/javs.2019.63436
Fayed, A., Salama, A., Ismaiel, I., Attia, T., A., E., Hassan, A. Protective Effects Of Solanium Nigrum Methanolic Extract Against Isoniazid/Rifampicin Induced Hepatotoxicity In Rats. Journal of Applied Veterinary Sciences, 2019; 4(2): 52-61. doi: 10.21608/javs.2019.63436

Protective Effects Of Solanium Nigrum Methanolic Extract Against Isoniazid/Rifampicin Induced Hepatotoxicity In Rats

Article 8, Volume 4, Issue 2, October 2019, Page 52-61  XML PDF (748.71 K)
Document Type: Original Article
DOI: 10.21608/javs.2019.63436
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Authors
Abdel Hameed M. Fayed email 1; Abeer A.A. Salama1; Ismaiel E Ismaiel1; Taha A. Attia2; Elbatran Seham A.1; Azza Hassan3
1Pharmacology Department National Research Centre, Giza, Egypt
2Pharmacology Department, Faculty of Vet. Med., El-Sadat University, Minoufiya, Egypt
3Pathology Department, Faculty of Vet. Med., Cairo University, Giza, Egypt
Receive Date: 23 August 2019,  Revise Date: 03 December 2019,  Accept Date: 25 September 2019 
Abstract
Drug-induced liver injury (DILI) is the major health problem that resulted from uses of many drugs especially from serious adverse effect of antituberculosis (ATT) drugs. forty eight rats (200-250g) were allocated into six groups (8 rats in each group), and treated as follow: group I: received normal saline orally; group II: received INH/RFP (50 mg/Kg/day of each) for 28 days orally; group III: received Silymarin (50 mg/kg/day) + INH/RFP for 28 days orally; group IV: received SNME(250 mg/Kg/day) + INH/RFP for 28 days orally; group V: received SNME (500 mg/Kg/day) + INH/RFP for 28 days orally; group VI, received SNME (1000 mg/Kg/day) + INH/RFP for 28 days orally. Co-administration of herbal plant (SNME) with INH/RFP reduced elevated serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and (bilirubin total &direct) levels but also decreased the elevated malondialdehyde (MDA) & tumor necrosis factor-α (TNF-α) contents in liver homogenate. Moreover, co-administration of herbal plant (SNME) with INH/RFP increased glutathione peroxidase (GPX) & adiponectin activity. Solanum nigrum administration to rats, in present study, led to a remarkable alteration of histological changes observed in INH/RFP group. It is concluded that Solanum nigrum might be considered as adjuvant drug in treatment of liver disorder and/or as hepatoprotective therapy with anti-tubercular drugs.
Keywords
Solanum nigrum; Hepatotoxicity; Isoniazid; Rifampicin; adiponectin; Rats
Main Subjects
Pharmacology and toxicology
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