Marek's disease salience in domestic poultry ,gross and a Histopathological study at Mosul city

Al-sabaawy, H.B.; Taha, A.N.; Almahmood, S.S.; N.A., Zad Elhana; Ajeel, Faten Saad

doi:10.21608/javs.2023.190440.1213

Marek's disease salience in domestic poultry ,gross and a Histopathological study at Mosul city

Document Type : Original Article

Authors

Department of Pathology and Poultry Diseases, Collage of Veterinary Medicine, University of Mosul, Iraq

10.21608/javs.2023.190440.1213

Abstract

ABSTRACT
Marek's diseases is a contagious disease affected chicken over all the world there are four different form of it and the infected birds may exhibit one or more from ( cutaneous ,visceral , ocular &neural) forms. MDV caused by infection of lymphocytes by Gallid alphherpesvirus 2,vaccines have been used successfully in many nations to control and stop the spread of the disease ,recent data indicates that vaccines effectiveness is declining now as a result of viral evolution .The current work was conducted from (July- November)of 2022 to diagnoses MD in a 20 naturally infected chicken from a total out 50 chicken which randomly received from different regions to the veterinary teaching hospital. Recent study research showed the present of gross and histopathological lesions of MDV infection represented by (2,4% in liver,1,6%in lung &kidney respectively,1,2% leg paralysis,0,8% in brain & finally spleen lesion was 0,4%) .The gross lesion characterized by hemorrhage ,congestion , splenomegaly, nodular lesion of liver & sprain of leg nerve , on the other hand the Histopathological lesions represented by congestion, degeneration& necrosis of hepatocytes , infiltration of monocular cell, vasogenic edema and spongy from cell inside brain tissue ,cell swelling and hyaline cast of renal tubules & lymphoproliferative foci with different size inside spleen parenchyma. From our result we conclude the occurrences of MDV in backyard chicken in different region of Mosul city

Keywords

Main Subjects

Pathology and clinical pathology

References

ABDUL, F,M., CAREEM,B, D., HUNTER, A,J., SARSON, A., MAYAMEEI,H., ZHOU, S., and SHARIF, S., 2006. Marek’s diseases virus-induced transient paralysis is associated with cytokine gene expression in the nervous system .journal Article Viral immunology .19(2)p167-176. https://doi.org/10.1089/vim.2006.19.167

AL-SABAAWY, H,B., RAHAWI,A,M., and AL-MAHMOOD, S,S., 2021. Standard techniques for formalin-fixed paraffin-embedded tissue: A Pathologist’s perspective. Iraqi Journal of Veterinary Sciences. 1; 35 (Supplement I-III):127–35. http://dx.doi.org/10.33899/ijvs.2021.131918.2023

BERTZBACH, L.D., CONRADIE, A,M., YOU,Y., and KAUFER, B,B., 2020. Latest Insights into Marek’s Disease Virus Pathogenesis and Tumorigenesis. Cancers. 10; 12 (3):647. https://doi.org/10.3390%2Fcancers12030647

BHUTIA, L,D., DAMODAR, and SINGH, Y., 2017. Occurrence of lymphoid leukosis in poultry population of Mizoram. Indian Journal of Veterinary Pathology; 41(3): 228-231. http://dx.doi.org/10.5958/0973-970X.2017.00056.6

BOODHOO, N., GURUNG, A., SHARIF, S., and BEHBOUDI, S., 2016. Marek’s disease in chickens: A review with focus on immunology. Vet. Res ;47:119. https://doi.org/10.1186/s13567-016-0404-3

DAS, S., DAS, D., PANDA, S.K., SAGARIKA, S., and JENA, B., 2018. Pathological Studies of Marek’s Disease in Chickens. Int. J. Livest. Res ;8:207–217. https://dx.doi.org/10.5455/ijlr.20170720115734

GIMENO, I.M. 2008. Marek’s disease vaccines: A solution for today but a worry for tomorrow Vaccine; 26:31–41 https://doi.org/10.1016/j.vaccine.2008.04.009

GIMENO, I.M. 2014. Marek’s Disease and Differential Diagnosis with Other Tumor Viral Diseases of Poultry. Encyclopedia of Agriculture and Food Systems; 156–71. https://doi.org/10.1016/B978-0-444-52512-3.00193-5

GIMENO, I, M., WITTER, H,D., HUNT, H,D., LEE, S,M., and REDDY,U., 2001. Marek's Disease Virus Infection in the Brain: Virus Replication, Cellular Infiltration, and Major Histocompatibility Complex Antigen Expression. Journal Article Veterinary Pathology, 38 ( 5)PP 491 to 503. https://doi.org/10.1354/vp.38-5-491

KENNEDY, D,A., GAIRNS, C., JONES,M, J., BELL, A,S., SALATHE, R,M., BAIGENT, S.J., NAIR, V,K., DUNN, P,A., and READ, A,F., 2017. Industry-Wide Surveillance of Marek’s Disease Virus on Commercial Poultry Farms. Avian Dis ;61:153–164. https://doi.org/10.1637/11525-110216-Reg.1

MENG, F., DONG, G., ZHANG, Y., TIAN, S., CUI, Z., and CHANG, S., 2018. Co-infection of fowl adenovirus with different immunosuppressive viruses in a chicken flock. Poult Sci;97(5):1699–705. http://dx.doi.org/10.3382/ps/pex414

PAYNE , L,N., and VENUGOPAL, K., 2000. Neoplastic diseases:Marek's disease, avian leukosis and reticuloendotheliosis. Rev. Sci. Tech. (Int. Office Epizoot.;19(2):544–564. https://doi.org/10.20506/rst.19.2.1226

RAVIKUMAR, R., SARAVANJAAYAM, M., MADHESWARAN, R., and TAMILAM, T.V., 2016. Occurrence of avian leucosis complex in commercial layer chicken raised in cages. Indian Veterinary Journal. 2016; 93(6):79-80. http://dx.doi.org/10.5958/0973-970x.2016.00024

SALEH,A., and KHOUDEIR, M., 2020. Preliminary Studies On The Virus Causing Outbreak Of Duckling Short Beak And Dwarfism Syndrome (Sbds) In Egypt. Journal of Applied Veterinary Sciences, 1;5 (4): 55–60. http://.doi.org/10.21608/javs.2020.118004

SEHA, S., DEBIPRASANNA, D., PAND, S,K., SPRIYA, D., BASANTI, J., RAJE.S. H., and KUMAR., 2017. Avian leukosis in chickens: A Clinico-pathological survey. Journal of Entomology and Zoology Studies; 5(6):1697-1701.

SUCHODOLSKI, P,F., IZUMIYA, Y., LUPIANI, B., AJITHDOSS, D,K., LEE, L.F., KUNG, H., and JREDDY, S,M., 2010.Both homo and heterodimers of Marek’s disease virus encoded Meq protein contribute to transformation of lymphocytes in chickens. Virology;399:312–321. https://doi.org/10.1016/j.virol.2010.01.006

WITTER, R.L. 2001. Protective Efficacy of Marek’s Disease Vaccines. Marek’s Disease ;57–90. http://.doi.org/10.1007/978-3-642-56863-3_3

ZHUANG, X., ZOU, H., SHI, H., SHAO, H., YE, J., and MIAO,J., 2015. Outbreak of Marek’s disease in a vaccinated broiler breeding flock during its peak egg-laying period in China. BMC Veterinary Research .23;11(1). http://.doi.org/10.1186/s12917-015-0493-7