A. Warda, S., I. Ali, N., F. Warda, F., Farouk, E., F. Farahat, L. (2021). Improvement Of Inactivated Equine Herpes Virus-1 Vaccine Using Carbomer. Journal of Applied Veterinary Sciences, 6(1), 21-27. doi: 10.21608/javs.2021.140080
Safaa A. Warda; Naglaa I. Ali; Fatma F. Warda; Ekbal M. Farouk; Lubna F. Farahat. "Improvement Of Inactivated Equine Herpes Virus-1 Vaccine Using Carbomer". Journal of Applied Veterinary Sciences, 6, 1, 2021, 21-27. doi: 10.21608/javs.2021.140080
A. Warda, S., I. Ali, N., F. Warda, F., Farouk, E., F. Farahat, L. (2021). 'Improvement Of Inactivated Equine Herpes Virus-1 Vaccine Using Carbomer', Journal of Applied Veterinary Sciences, 6(1), pp. 21-27. doi: 10.21608/javs.2021.140080
A. Warda, S., I. Ali, N., F. Warda, F., Farouk, E., F. Farahat, L. Improvement Of Inactivated Equine Herpes Virus-1 Vaccine Using Carbomer. Journal of Applied Veterinary Sciences, 2021; 6(1): 21-27. doi: 10.21608/javs.2021.140080
Improvement Of Inactivated Equine Herpes Virus-1 Vaccine Using Carbomer
1Department of Equine Vaccines Research, Veterinary Serum and Vaccine Research Institute (VSVRI), Agricultural Research Center (ARC), Egypt
2Department of Pet Animal Vaccines Research, Veterinary Serum and Vaccine Research Institute (VSVRI), Agricultural Research Center (ARC), Egypt.
3Department of Equine Vaccines Research, Veterinary Serum and Vaccine Research Institute (VSVRI), Agricultural Research Center (ARC), Egypt.
4Department of Foot and Mouth Disease Vaccine Research, Veterinary Serum and Vaccine Research Institute (VSVRI), Agricultural Research Center (ARC), Egypt.
5Department of Sera and Antigens Research, Veterinary Serum and Vaccine Research Institute (VSVRI), Agricultural Research Center (ARC), Egypt.
Receive Date: 16 November 2020,
Revise Date: 22 December 2020,
Accept Date: 27 December 2020
Abstract
An inactivated Equine herpes virus-1 vaccine was successfully improved using carbomer as adjuvant inducing high and long immunity in vaccinated mares in comparison with the convention one adjuvanted with Al-hydra gel and saponin. Such purpose was established by using 0.5% carbomer as adjuvant to the inactivated EHV-1. The applied quality control tests carried out on such vaccine revealed that it is free from foreign contaminants, safe in pregnant mares and mice and potent induced high levels of specific EHV-1 antibodies in vaccinated Guinea pigs and mares as measure by ELISA and SNT. This immunity was sufficient to protect vaccinated horses up to 28 weeks (7months) post-vaccination.
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