Efficacy Of Using Carbopol As An Adjuvant For Tissue Culture Inactivated Rabies Vaccine

Aly, Naglaa I.; A. E. El-Shamandy, Omaima; M.B., Shendy; F. Warda, Fatma; M. Farouk, Ekbal

doi:10.21608/javs.2020.103395

Efficacy Of Using Carbopol As An Adjuvant For Tissue Culture Inactivated Rabies Vaccine

Document Type : Original Article

Authors

¹ Department of Pet Animal Vaccine Research, Veterinary Serum and Vaccine Research Institute (VSVRI) Abbasia Cairo Egypt

² Department of Pet Animal Vaccine Research, Veterinary Serum and Vaccine Research Institute (VSVRI), Agriculture Research Center, Abassia, Cairo, Egypt.

10.21608/javs.2020.103395

Abstract

In a trail to improve rabies vaccine's immunogenicity, water-soluble acrylic acid (carbopol) was used as an adjuvant in the prepared vaccine. The potency test of the National Institute of Health revealed that the prepared vaccine is potent and efficient. Studying the dynamics of serum antibody in vaccinated dogs using serum neutralizing antibodies test and ELISA showed that antibody titer (0.9 and 1.2352 respectively) reached a level considered protective within two weeks and increased till lasted consist ant (2.4 and 2.694) during the experiment for about twenty-four weeks. In conclusion, the present study results indicated that the vaccine formulated according to this study procedure could provoke long-lasting protective immune response after a single dose administration without any adverse reaction.

Keywords

Main Subjects

Immunology and Vaccinology

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