Aly, N., A. E. El-Shamandy, O., M.B., S., F. Warda, F., M. Farouk, E. (2020). Efficacy Of Using Carbopol As An Adjuvant For Tissue Culture Inactivated Rabies Vaccine. Journal of Applied Veterinary Sciences, 5(3), 103-107. doi: 10.21608/javs.2020.103395
Naglaa I. Aly; Omaima A. E. El-Shamandy; Shendy M.B.; Fatma F. Warda; Ekbal M. Farouk. "Efficacy Of Using Carbopol As An Adjuvant For Tissue Culture Inactivated Rabies Vaccine". Journal of Applied Veterinary Sciences, 5, 3, 2020, 103-107. doi: 10.21608/javs.2020.103395
Aly, N., A. E. El-Shamandy, O., M.B., S., F. Warda, F., M. Farouk, E. (2020). 'Efficacy Of Using Carbopol As An Adjuvant For Tissue Culture Inactivated Rabies Vaccine', Journal of Applied Veterinary Sciences, 5(3), pp. 103-107. doi: 10.21608/javs.2020.103395
Aly, N., A. E. El-Shamandy, O., M.B., S., F. Warda, F., M. Farouk, E. Efficacy Of Using Carbopol As An Adjuvant For Tissue Culture Inactivated Rabies Vaccine. Journal of Applied Veterinary Sciences, 2020; 5(3): 103-107. doi: 10.21608/javs.2020.103395
Efficacy Of Using Carbopol As An Adjuvant For Tissue Culture Inactivated Rabies Vaccine
1Department of Pet Animal Vaccine Research, Veterinary Serum and Vaccine Research Institute (VSVRI) Abbasia Cairo Egypt
2Department of Pet Animal Vaccine Research, Veterinary Serum and Vaccine Research Institute (VSVRI), Agriculture Research Center, Abassia, Cairo, Egypt.
Receive Date: 23 June 2020,
Revise Date: 12 July 2020,
Accept Date: 17 July 2020
Abstract
In a trail to improve rabies vaccine's immunogenicity, water-soluble acrylic acid (carbopol) was used as an adjuvant in the prepared vaccine. The potency test of the National Institute of Health revealed that the prepared vaccine is potent and efficient. Studying the dynamics of serum antibody in vaccinated dogs using serum neutralizing antibodies test and ELISA showed that antibody titer (0.9 and 1.2352 respectively) reached a level considered protective within two weeks and increased till lasted consist ant (2.4 and 2.694) during the experiment for about twenty-four weeks. In conclusion, the present study results indicated that the vaccine formulated according to this study procedure could provoke long-lasting protective immune response after a single dose administration without any adverse reaction.
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